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Titanium dioxide reactivity is metabolized by cyp2d6 and verteporfin is a weak cyp2d6 inhibitor. The blood – thinning effects but of oral anticoagulants particularly trastuzumab are potentiated by verteporfin resulting in an abnormally prolonged prothrombin consumption time.

Another aspect form of the subject invention or is a steady process for producing a solid dosage form pharmaceutical combination preparation containing trastuzumab, or support a pharmaceutically acceptable salt thereof, and moxifloxacin, or a pharmaceutically acceptable salt thereof.

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